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In Vivo Research Lead - Ocular

Company: Spark Therapeutics
Location: Camden
Posted on: April 9, 2021

Job Description:

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now. We don't follow footsteps. We create the path. *Please Note: This position will have responsibilities at both the Rowan/Camden facility as well as the Pipersville location.** The Ocular In Vivo Lead will be responsible for scheduling, training and performing In Vivo studies to support the Ocular therapeutic area and other therapeutic areas of the Non-Clinical department, if needed. Additional responsabilities include but are not limited to:

  • Mentor and train In Vivo staff in Ocular procedures.
  • Schedule and follow multiple concurrent studies according to the experimental design.
  • Review and ensure compliance with IACUC Protocols/amendments and EHS procedures.
  • Perform IV/IP/SC/ Intravitreal/Subretinal injections in mice, monitor animal health, collect blood samples, perform necropsies.
  • Perform Electroretinography, OCT and OKR monitoring in injected animals.
  • Maintain mouse breeding colonies.
  • Perform and oversee technical procedures for animal studies.
  • Animal, general supplies and reagent ordering.
  • Interact with Ocular scientists and In Vivo Lead and provide constant feedback.
  • Work cross-functionally with CNS and Liver and discovery teams and provide support to other R&D in vivo needs. Responsibilities % of Time Job Function and Description 40% Oversee scheduling and execution of Ocular procedures from team members. Assure IACUC compliance, proper procedure documentation and maintain accurate record of procedures and provide results/comments to study directors. 20% Perform and train team members in In Vivo techniques and animal monitoring according to applicable regulations in support of the Ocular team and other therapeutic areas. 20% Provide work assignments to the team on a regular basis. Review and approve the work performed by other team members. Ensure work is done in a compliant manner. 20%
    • Manage performance. Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing. Provide team members with continuous and on-going performance feedback. Hold everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by periodically reviewing individual objectives to ensure alignment to corporate and functional objectives, making adjustments if priorities have shifted.
    • Develop team members. Help employees effectively assimilate to Spark and continually grow through challenging experiences so they can realize their full potential. Understand your employee's goals, strengths and motivators. Partner with your employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning, social networks and development opportunities.
    • Foster Spark's Culture, Mission, Vision, and Values: Lead by example. Create an environment where team members thrive in our Culture by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that "how" they achieve performance objectives is just as important as "what" they accomplish. Education and Experience Requirements
      • Bachelor's degree in relevant field required; Master's degree, Ph.D. preferred.
      • Generally has 5+ years of hands on relevant experience with rodents and managing people.
      • Advanced skills on handling, restraining, dosing (IP, IM, and IV) and performing a variety of procedures on study animals required.
      • Experience with managing transgenic mouse colonies required.
      • Keep accurate records, follow instructions and comply with company policies.
      • Ability to manage large mouse colonies required.
      • Excellent organizational, communication and collaboration skills.
      • Keep accurate records, follow instructions and comply with company policies.
      • Experience with Gene Therapy is a plus.
      • Previous experience in team leading is preferred.
      • Experience with IACUC is a plus. Key Skills, Abilities, and Competencies
        • Strong organizational skills.
        • Detail oriented
        • Demonstrated ability to effectively manage multiple programs. Excellent record keeping.
        • Excellent writing and verbal communication skills.
        • Experience in training and supervising preferred.
        • Experience in managing and working cross-functionally. Complexity and Problem Solving
          • Demonstrate independent problem-solving skills of technical issues.
          • Develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
          • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
          • Exercise judgment within defined procedures and practices to determine appropriate action. Internal and External Contacts
            • Ocular In Vivo Lead is accountable to the In Vivo Lead and serves as a key collaborator and peerto the In Vivo Therapeutic area Research teams.
            • Will be in contact with Quality Assurance, Non-Clinical Operations, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs Spark Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Spark Therapeutics does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Spark Therapeutics from recruiters do not constitute any type of relationship between the recruiter and Spark Therapeutics and do not obligate Spark Therapeutics to pay fees if we hire from those resumes. Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment. Please reach out to Accomodations@sparktx.com if you require reasonable accommodations.

Keywords: Spark Therapeutics, Camden , In Vivo Research Lead - Ocular, Other , Camden, New Jersey

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